Talk Python To Me
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Talk Python To Me
Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly lear...
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#541: Monty - Python in Rust for AI
When LLMs write code to accomplish a task, that code has to actually run somewhere. And right now, the options aren't great. Spin up a sandboxed conta...
#540: Modern Python monorepo with uv and prek
Monorepos -- you've heard the talks, you've read the blog posts, maybe you've seen a few tantalizing glimpses into how Google or Meta organize their m...
#539: Catching up with the Python Typing Council
You're adding type hints to your Python code, your editor is happy, autocomplete is working great. But then you switch tools and suddenly there are re...
#538: Python in Digital Humanities
Digital humanities sounds niche, until you realize it can mean a searchable archive of U.S. amendment proposals, Irish folklore, or pigment science in...
#537: Datastar: Modern web dev, simplified
You love building web apps with Python, and HTMX got you excited about the hypermedia approach -- let the server drive the HTML, skip the JavaScript b...
#536: Fly inside FastAPI Cloud
You've built your FastAPI app, it's running great locally, and now you want to share it with the world. But then reality hits -- containers, load bala...
#535: PyView: Real-time Python Web Apps
Building on the web is like working with the perfect clay. It’s malleable and can become almost anything. But too often, frameworks try to hide the we...
#534: diskcache: Your secret Python perf weapon
Your cloud SSD is sitting there, bored, and it would like a job. Today we’re putting it to work with DiskCache, a simple, practical cache built on SQL...
#533: Web Frameworks in Prod by Their Creators
Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in pro...
#532: 2025 Python Year in Review
Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packaging is getting sharper tools, and the type checkers are multi...
#531: Talk Python in Production
Have you ever thought about getting your small product into production, but are worried about the cost of the big cloud providers? Or maybe you think...
#530: anywidget: Jupyter Widgets made easy
For years, building interactive widgets in Python notebooks meant wrestling with toolchains, platform quirks, and a mountain of JavaScript machinery....
#529: Computer Science from Scratch
A lot of people building software today never took the traditional CS path. They arrived through curiosity, a job that needed automating, or a late-ni...
#528: Python apps with LLM building blocks
In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another API in your Python app, with clear boundaries, small focused e...
#527: MCP Servers for Python Devs
Today we’re digging into the Model Context Protocol, or MCP. Think LSP for AI: build a small Python service once and your tools and data show up acros...
#526: Building Data Science with Foundation LLM Models
Today, we’re talking about building real AI products with foundation models. Not toy demos, not vibes. We’ll get into the boring dashboards that save...
#525: NiceGUI Goes 3.0
Building a UI in Python usually means choosing between "quick and limited" or "powerful and painful." What if you could write modern, component-based...
#524: 38 things Python developers should learn in 2025
Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In...
#523: Pyrefly: Fast, IDE-friendly typing for Python
Python typing got fast enough to feel invisible. Pyrefly is a new, open source type checker and IDE language server from Meta, written in Rust, with a...
#522: Data Sci Tips and Tricks from CodeCut.ai
Today we’re turning tiny tips into big wins. Khuyen Tran, creator of CodeCut.ai, has shipped hundreds of bite-size Python and data science snippets ac...
#521: Red Teaming LLMs and GenAI with PyRIT
English is now an API. Our apps read untrusted text; they follow instructions hidden in plain sight, and sometimes they turn that text into action. If...
#520: pyx - the other side of the uv coin (announcing pyx)
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#519: Data Science Cloud Lessons at Scale
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#518: Celebrating Django's 20th Birthday With Its Creators
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#517: Agentic Al Programming with Python
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#516: Accelerating Python Data Science at NVIDIA
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#515: Durable Python Execution with Temporal
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#514: Python Language Summit 2025
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#513: Stories from Python History
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#512: Building a JIT Compiler for CPython
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#511: From Notebooks to Production Data Science Systems
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#510: 10 Polars Tools and Techniques To Level Up Your Data Science
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#509: GPU Programming in Pure Python
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#508: Program Your Own Computer with Python
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#507: Agentic AI Workflows with LangGraph
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#506: ty: Astral's New Type Checker (Formerly Red-Knot)
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#505: t-strings in Python (PEP 750)
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#504: Developer Trends in 2025
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#503: The PyArrow Revolution
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#502: Django Ledger: Accounting with Python
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