a16z Podcast
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a16z Podcast
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valle...
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The State of AI: Macro, Apps, and Consumer
Anish Acharya joins Jen Kha to break down the next frontier of AI, from the evolving model landscape and open-source AI to why the application layer,...
The New Economics of AI | Martin Casado & Steven Sinofsky
a16z General Partners Martin Casado and Erik Torenberg are joined by Board Partner Steven Sinofsky to explore what recent breakthroughs in AI and math...
Why Medical AI Needs a Referee | Protege's Engy Ziedan
Daisy Wolf and Eva Steinman are joined by Engy Ziedan, co-founder and Chief Scientific Officer of Protege, to discuss why medical AI has a measurement...
Martin Casado on Where the Value Is Going in AI
Martin Casado joins MTS hosts Theo Jaffee and Sophia Dew to unpack where value is actually accruing in AI, why this technology cycle looks fundamental...
How Microsoft Is Securing the Agentic Enterprise | Aaron Zollman
a16z's Joel De La Garza is joined by Aaron Zollman, Deputy CISO at Microsoft Gaming, to discuss how security teams can embrace AI agents without losin...
How Global Networks Are Reshaping Startup Success
Elena Burger is joined by a16z’s Angela Strange and Gabriel Vasquez to discuss the rise of the "borderless founder": entrepreneurs who bring the netwo...
How Whatnot Built a Global Marketplace
a16z General Partner David George is joined by Grant LaFontaine, co-founder of Whatnot, to unpack how a marketplace that started with collectibles evo...
How Do You Defend Against AI That Can Hack?
a16z's Joel De La Garza is joined by Nick Warner of Neo and Max Pollard of Cotool to discuss what happens when cybersecurity tools built to defend aga...
Stripe’s AI Strategy: Build More, Not Less
a16z General Partner David George is joined by Will Gaybrick, President of Product & Business at Stripe, to discuss how AI is changing the way Stripe...
Ben Horowitz and Travis Kalanick on Building Again
Ben Horowitz, Travis Kalanick, and Erik Torenberg take the stage at Atoms' launch event for a candid fireside conversation about entrepreneurship, com...
The Two Ways to Sell AI: Lighthouse or Landgrab?
Elena Burger is joined by a16z's Andy McCall and Joe Schmidt to break down two very different ways AI startups can go to market: the lighthouse and th...
Garry Tan on Taste, Agents and Founder Ambition
Anish Acharya is joined by Garry Tan, President and CEO of Y Combinator, for a conversation about how AI is rewriting the startup playbook, why founde...
The CISO Playbook for AI Agents | Datadog
a16z's Joel De La Garza is joined by Emilio Escobar, Chief Information Security Officer at Datadog, to discuss what it takes to secure a company where...
How Kavak Rebuilt Itself Around AI Agents | Alejandro Maza Ayala
Angela Strange and Gabriel Vasquez are joined by Alejandro Maza Ayala, Chief Product & AI Officer at Kavak, to unpack how the Latin American used-car...
The Reality of AI-Powered Cyberattacks | Truffle Security & Socket
Joel De La Garza is joined by Dylan Ayrey, co-founder and CEO of Truffle Security, and Feross Aboukhadijeh, founder and CEO of Socket, to discuss one...
How Open-Source AI Became Critical Infrastructure
Elena Burger and Matt Bornstein are joined by Simon Mo, co-founder and CEO of Inferact, the open-source inference engine powering many of today's most...
Three Startups Reinventing Critical Infrastructure
This week, a16z American Dynamism Films premiered three short documentaries highlighting companies tackling some of America's biggest industrial chall...
OpenAI's Joshua Achiam: Did We Already Reach AGI?
Theo Jaffee is joined by Joshua Achiam, Chief Futurist at OpenAI, for a conversation on AI cybersecurity, frontier model capabilities, and why he beli...
Ruby Thelot on Internet Culture, AI, and the Future of Taste
Sophia Dew and Sofia Puccini are joined by Ruby Thelot, designer, artist, cyberethnographer, professor at NYU, and founder of 13101401, for a wide-ran...
Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation
Marc Andreessen, Chris Dixon, and Robert Hackett discuss one of the most consequential policy debates facing the crypto industry: the push for compreh...
Decagon’s Playbook for Building Enterprise AI Applications
Sarah Wang and Kimberly Tan are joined by Jesse Zhang and Ashwin Sreenivas, co-founders of Decagon, to discuss the evolution of enterprise AI agents,...
AI for America's Small Businesses | Lassie
Alex Rampell and Olivia Moore speak with Lassie cofounders Steijn Pelle and Frédéric Renken about bringing AI to one of the most overlooked parts of t...
AI Micro Dramas, Generative Media, and the Future of Creativity
Justine Moore, partner at Andreessen Horowitz, joins New Economies to explore the rapid evolution of generative media and why AI-native content is rea...
Fei-Fei Li on Spatial Intelligence and Robotics
Last week, World Labs announced its acquisition of SceniX, bringing together two teams working on one of AI's biggest unsolved problems: how to give m...
Steven Sinofsky: AI Doesn't Need New Rules Yet
Steven Sinofsky joins Theo Jaffee and Sofia Puccini for a conversation on AI regulation, open-source models, and what history can teach us about techn...
Ben Horowitz: The Fight Over Open Source AI
Ben Horowitz joins Theo Jaffee and Sofia Puccini to discuss one of the biggest debates in AI today: the future of open-source models. They examine the...
Sriram Krishnan on Open Source AI's Biggest Week Yet
Sriram Krishnan joins Theo Jaffee and Sofia Puccini just after concluding his tenure as Senior White House Policy Advisor on AI to discuss one of the...
Building the Physical AI Stack | Travis Kalanick on TBPN
Travis Kalanick joins TBPN to discuss Atoms, his vision for industrial AI, and why he believes the biggest opportunities in AI lie beyond software.
Travis Kalanick Is Back | Building the Future of Industrial AI
Travis Kalanick, Ben Horowitz, and Erik Torenberg reunite to reflect on Uber's early days, the investment that almost happened, and why Kalanick belie...
Why Physical AI Is the Next Frontier | Applied Intuition
Applied Intuition has spent the past decade building the software that powers intelligent machines, from passenger vehicles and trucks to defense syst...
Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition
As governments weigh new restrictions on frontier AI models, one question is becoming increasingly important: what role should open source play in the...
Amjad Masad on Going Direct, Building Replit, and the Future of Software
Recorded live at the New Media Summit, Erik Torenberg sits down with Replit founder and CEO Amjad Masad to discuss founder-led storytelling, building...
Replay 2025: David Sacks on AI, Crypto, and America's Technology Future
As part of our summer replay series, we're revisiting one of our most-discussed conversations from the past year.
David Sacks joins Marc Andrees...
Can Anyone Catch NVIDIA? | The Future of Chips and Infrastructure
As part of our summer replay series, we're revisiting one of our favorite conversations on the future of AI infrastructure.
SemiAnalysis founder...
Is AI a Bubble? | Gavin Baker on Data Centers, GPUs, and the AI Economy
As part of our summer replay series, we're revisiting one of the standout conversations from Runtime, a16z's conference on AI infrastructure and the f...
Before Blockchains, There Was State Machine Replication
Every blockchain today relies on replication techniques first developed in the 1980s by researchers who weren't thinking about cryptocurrencies at all...
How Bitcoin Rewired a Classic Computer Science Problem
We're excited to share a special feed drop from The a16z Crypto Show.
In the first episode of First Principles: The Scientific Roots of Blockcha...
Mark Zuckerberg & Priscilla Chan: How AI Will Help Cure Disease
As part of our summer replay series, we're revisiting one of our favorite conversations from the past year.
Mark Zuckerberg and Dr. Priscilla Ch...
Adam Neumann: This Is How You Build Iconic Companies
Adam Neumann joins Marc Andreessen, Ben Horowitz, and Erik Torenberg for a candid conversation about entrepreneurship, failure, and building Flow.
Is Software Losing Its Head?
Seema Amble, Steven Sinofsky, and Elena Burger unpack one of the biggest questions facing enterprise software: what happens when AI agents become the...